How do SSRIs work?

Posted by Klavot on January 14, 2007, at 5:36:12

SSRIs inhibit reuptake of 5HT by 60 - 80 % or something, thus causing presynaptic concentrations of 5HT to increase. Obviously this process cannot continue unhindered, otherwise your presynaptic concentrations of 5HT would rise to toxic levels - a bit like a blocked drain where you just keep adding water. So what happens to prevent 5HT levels from rising too much? Does your brain compensate by making less 5HT? Does MAO enzyme activity increase? Or what?
Klavot

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How do SSRIs work? Klavot 1/14/07
Re: How do SSRIs work? » Klavot Phillipa 1/14/07
Re: How do SSRIs work? blueberry1 1/15/07
Re: How do SSRIs work? laima 1/15/07
Re: How do SSRIs work? » laima Phillipa 1/15/07

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poster: Klavot thread:722137
URL: http://www.dr-bob.org/babble/20070113/msgs/722137.html

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