Posted by Tomatheus on January 11, 2007, at 21:38:05
In reply to Re: SSRIs and Elevated Cortisol- other Antidepressants, posted by bulldog2 on January 11, 2007, at 15:35:45
> Anyone know how the maois effect cortisol?
Phenelzine (Nardil's active ingredient) has been shown to increase hypothalamic-pituitary-adrenocortical (HPA) activity in mice (Kier et al., 2005).
Interestingly, even though major depressive disorder is most commonly associated with abnormally high HPA activity, atypical depression and seasonal affective disorder are often associated with abnormally low HPA activity. Atypical depressives tend to respond preferentially to MAOIs.
Tomatheus
==
REFERENCE
Kier, A., Han, J., & Jacobson, L. (2005). Chronic treatment with the monoamine oxidase inhibitor phenelzine increases hypothalamic-pituitary-adrenocortical activity in male C57BL/6 mice: Relevance to atypical depression. Endocrinology, 146, 1338-1347. Abstract: http://endo.endojournals.org/cgi/content/abstract/146/3/1338
poster:Tomatheus
thread:721345
URL: http://www.dr-bob.org/babble/20070107/msgs/721513.html