Posted by yxibow on January 6, 2007, at 23:23:51
In reply to Re: Remeron, anxiolysis, posted by saturn on January 6, 2007, at 22:53:15
> > Didn't do anything for my anxiety . . . just puts me to sleep. It is the kind of groggy sleepiness characteristic of antihistamines like those found in cough syrups.
>
> It made me feel very calm. Sedated also, but a distinct calmness as well. I do not know if this is the antihistamine action or 5-HT2/3 antagonism or what.
>I personally believe when I took it, not my doctor's belief necessarily, that at a high enough dose the 5HT blockade is similar to an atypical neuroleptic without the D2 action. The alpha adrenergic may be a primary action of the drug but the other blockade does play a role.
The sedation though also probably provides some of the anxiolytic action as all heavily sedating agents. In fact if I look at the list of my medications, there is one thing in common with a lot of them -- they are sedating. Sure, one gets used to it -- but only in part.
-- tidings.
poster:yxibow
thread:719997
URL: http://www.dr-bob.org/babble/20070101/msgs/720028.html