Posted by Vale on December 17, 2006, at 15:54:26
In reply to Re: Do APs block the euphoric effects of opiates?, posted by Quintal on December 17, 2006, at 9:03:24
>Hello Quintal
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> I'm curious about the 'neuroleptic flavour' you talk about. Amisulpride felt nothing like any other AP I've taken - it felt very similar to the other dopamine agonists to me. It made me feel light and energetic - even euphoric at the beginning. I seemed much more alert and mentally sharp. The negative side effects I normally associate across the spectrum of APs are heavy sedation, mental slowing/cognitive impairment, vacant facial expression/zoning out etc, anhedonia/dysphoria, akathisia/restlessness, parkinsonism, dystonia and other EPS. None of these were a problem for me with amisulpride in doses of 50mg and below, and I didn't notice any problems at 150mg either - it just seemed to lose its energising effect.Yes, it makes most people energized and alert, me too, I'm talking about a hard to define perception of how things are perceived under it's influence, rather than distinct side effect profiles like you mention.For me that perception comes closest to an A.P. rather then a dopamine agonist. It's not a dopamine agonist anyway, though it's reputed preferential pre-synaptic blocking mechanism at low dosage may contribute to the initial activating effects.
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> Hydroxyzine is not an antipsychotic and can't be compared to them for this purpose. Some antipsychotics are piperazine derivatives but piperazine derivatives vary as widely as Viagra, pesticides and cattle wormers which are clearly not antipsychotics. The piperazines, particularly BZD, MCPP and TFMPP are being used in 'Pep Pills' here in the UK (and are rapidly being outlawed) as they are powerful stimulants and are marketed as legal harm-reduction amphetamine and ecstasy alternatives.Hydroxycine in it's subjective effects can quite definitely be compared to A.P's.( sedation, and the who cares feeling), It may also cause similar side effects, notably EPS and tardive dyskinesia.
Though granted, it's use in clinical practice, is mainly for pre and post operative sedation, and as an antihistamine.( we are a long way from pep pills and cattle dewormer with this one)
If we go back in time to the early 50's, the first authentic A.P. chlorpromazine was an offshoot of an antihistamine experiment. (The Tri-cyclic A.D.'s are further tweaked relatives of this group of compounds)Thanks for the stimulating interchange,
A Merry Christmas and a Happy drug free new year.Vale
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poster:Vale
thread:713536
URL: http://www.dr-bob.org/babble/20061217/msgs/714614.html