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Re: tianeptine with other drugs

Posted by blueberry1 on December 16, 2006, at 9:15:16

In reply to tianeptine with other drugs, posted by Jon Rollins on December 15, 2006, at 19:08:59

I think trying to predict how tianeptine would work with other drugs like neuroleptics is a fruitless game and that only a personal trial will tell. So often what appears logical in theory just doesn't work that way, sometimes for better and sometimes for worse.

I did read an abstract at pubmed.com where a treatment resistent patient who had not responded to traditional antidepressants or to tianeptine did respond well to a combination of them. They actually combined tianeptine with another antidepressant. No mention of what the other antidepressant was though. It doesn't make sense that a reuptake inhibitor combined with a reuptake enhancer would work. But it did. I think the mechanisms of all these drugs on other systems besides just the monoamines is very complicated, and may sometimes be more important than what they actually do to serotonin.


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