Posted by dessbee on December 13, 2006, at 6:04:32
In reply to Propranolol safe for long term use with normal BP?, posted by linkadge on December 12, 2006, at 17:07:37
I think Propranolol may be helpful.
"The most striking findings of this study were the pronounced activation of the central noradrenergic system in patients with melancholic depression and the data indicating that cortisol is likely to play several roles in producing and sustaining the depressive syndrome. Several implications for future therapeutic intervention in major depression with melancholic features emerge from these findings. First, the potential efficacy of an alpha-noradrenergic blocker should be investigated. Second, given the positive correlation between plasma cortisol and NE levels and the capacity of glucocorticoids to also potentiate the activity of the descending hypothalamic and amygdala CRH pathways, further trials of glucocorticoid antagonism should be conducted in patients with major depression with melancholic features. "
poster:dessbee
thread:712939
URL: http://www.dr-bob.org/babble/20061212/msgs/713164.html