Posted by dessbee on December 13, 2006, at 5:14:51
Found some interesting articles about reduced glucocorticoid receptor densisty in mice causes depressionlike behaviors,
HPA axis dysfunction and decrease in BDNF when exposed to stress.This may be critical in the pathogenesis of depression, since glucocorticoid receptors inhibit release of CRH.
http://www.physiology.emory.edu/FIRST/pdfs/Neigh_Nemeroff_2006.pdf
http://www.biopsychiatry.com/glucocorticoidreceptor.htm
Another study shows how dynamic the glucocorticoid receptor density is.
Neonatal handling resulted in increased hippocampal glucocorticoid receptor density, which implies an increased HPA axis sensitivity.
Results also showed that handling increased BDNF.http://bmc.ub.uni-potsdam.de/1744-859X-4-8/
poster:dessbee
thread:713163
URL: http://www.dr-bob.org/babble/20061212/msgs/713163.html