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Re: Ketamine » tessellated

Posted by Quintal on December 12, 2006, at 21:33:21

In reply to Re: Ketamine, posted by tessellated on December 12, 2006, at 21:09:25

>-how can you know the difference?

Between Ketamine's effect on neurotransmitters and the psychedelic experience? That isn't quite what I meant. Obviously the psychedelic effects are caused by Ketamine's NMDA antagonism or some other action on the brain, but those effects aren't seen with SSRIs or antipsychotics and are certainly not their mode of action. I'm guessing that it's the personal insights or perhaps just the profound shift in consciousness - the dissociation - that sets the antidepressant effect of Ketamine apart from conventional antidepressant drugs. A bit like psychedelic therapy.

I've read from some sources that believe a substantial portion of the beneficial effect of ECT is due to the general anaesthetic alone. I'll try and find a link.

Q


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