Posted by yxibow on December 10, 2006, at 19:11:23
In reply to Why Are Dopamine Agonists Not More Popular?, posted by blueberry on December 10, 2006, at 18:31:27
> I was wondering why we don't see more mention of dopamine agonists such as requip-ropinirole or mirapex-pramipexole here at pbabble. Realizing mileage varies, these drugs do look pretty decent in literature anyway, for depression, augmentation of antidepressants or mood stabilizers, sexual dysfunction from antidepressants, and bipolarII depression. I wonder why they aren't more popular. It looks like their biggest side effects are somnolence and dizziness. Maybe that's it? Or do they just not work as good in the real world as they do in trials? Or are doctors mainly focused on the serotonin meds? It seems like the dopamine approach would be more popular than it is. ???
For one reason, D2/D3 agonists while they may adjust an imbalance / improve a condition in Bipolar in trials for some, they unfortunately also can cause hallucinations, activating that region of the brain in the same way that schizophrenia can.
Parkinsons patients who take carbidopa-levodopa may have to take Zyprexa (possibly), Seroquel, or Clozaril to counteract some of these symptoms and it is a delicate balance of course there because they can't take much of a stronger neuroleptic.
poster:yxibow
thread:712252
URL: http://www.dr-bob.org/babble/20061206/msgs/712261.html