Posted by Quintal on December 10, 2006, at 13:41:42
In reply to Re: Tricyclics » Quintal, posted by yesac on December 10, 2006, at 12:24:21
>I haven't tried Nardil either. Mainly because I had such a bad response to Parnate (it made me more depressed and very flat and dull). I don't know how similar they are. But I'm not excited about the diet so I guess I'd rather try other things first.
Parnate also made me feel much more depressed and anxious at low doses (30mg). I only began to feel a positive response in the 80-120mg dose range after a few weeks - in combo with Klonopin. Having a bad response to Parnate doesn't necessarily predict a poor result with Nardil. Nardil has quite a different profile and may be beneficial.
>Of the SSRIs, Celexa and Paxil basically did nothing. I mean I didn't even have any side effects. It was like I wasn't taking them at all. Prozac made me very agitated, homicidal, and revved up.
Perhaps try Zoloft up to the max dose then?
>But I'm curious... why do you suggest combining an ineffective AD with Lamictal, which was also ineffective for me?
I did not suggest combining an *ineffective* AD with Lamictal, I believe that was your own suggestion yesac. I put forward the idea of combining Lamictal with the AD you found the *most effective* (assuming of course you had found any AD beneficial in some way) on the grounds of Lamictal being widely recognised as an augmenter. I was hoping you would find a greater response that AD (I was assuming of course you had found at least *some* small benefit from at least one AD in the pharmacopoeia).
>I'm honestly not sure that there is one that was effective at all. Maybe Cymbalta. Maybe EMSAM. But neither did enough that I felt like I actually felt much better.
Then as you say, the AD plus Lamictal combo is unlikely to be worthwhile. Please disregard it.
>I'm a bit puzzled by this whole drug combination/augmentation concept. I mean, I understand it if a drug is helping a little bit, or if there are some side effects that another drug might counteract, or if there are some symptoms that don't improve on just the one drug.
Lamictal has been effective as an augmenter for some treatment resistant patients. There are references I could find to support this, but it's a pain in the *ss to go and dig them out. I don't pretend to know the exact pharmacological mechanisms of this cocktail, I'm not sure anyone does know for sure, I'm just trying to provide what I think may be helpful suggestions to people who are trapped between a rock and a hard place. Obviously if you think a particular idea is rubbish feel free to disregard it.
Q
poster:Quintal
thread:711506
URL: http://www.dr-bob.org/babble/20061206/msgs/712192.html