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Mood stabilizers and AD's

Posted by tensor on December 3, 2006, at 9:01:15

I have tried Lithium as an augmentor for my AD's and as a mood stabilizer to prevent relapses in depression(unipolar). No success. My lamictal
trial is probably coming to an end soon as it has no antidepressant properties for me whatsoever, it just makes me tired. My question is, is there any point trying other mood stabilizers/anticonvulsants like carbamazepine, valproate or oxcarbazepine? Their actions are pretty similar. I'm not too keen trying antipsychotics, what do you think, is it the next logical step?

I would like a med with a little stimulant effect, but that's not the first priority, AD effect is. I have responded best to noradrenergic meds, and I read somewhere that T3 increases NE receptor sensitivity. Could it be that my NE receptors gets desensitized over time and thus causing a relapse? I'm trying to put together a list of a few strategies(or at least one) to show my pdoc at next appoinment(20 dec.). I can't endure Lamictal much longer, I have been patient.

I'm not sure if it's of any significance but when I crash, I go from euthymia to depression in one or two days and then I stay depressed for a very long time. It's strange.

Dopamine and the reward system seems to be in "off mode", however, I have no problems with my humour, I laugh at funny things and often comes up funny things, like jokes. Difficulties falling asleep but sleep well when I does. Often tempted to binge eat, but can withstand pretty good. Lack of motivation, energy and interest. That are the characteristics of my depression.

Please, suggestions, opinions, ideas and comments greatly appreciated.

/Mattias


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