Posted by linkadge on November 30, 2006, at 10:12:14
In reply to Re: Maybe all drugs are like this » linkadge, posted by Squiggles on November 30, 2006, at 8:08:52
>actually effect the same areas of the brain
Lithium and valproate are similar on certain domains. Their ability to inhibit PKC-epsilon, GSK-3b, and increase BCL-2, and BDNF, but they are *not* identical in all their actions.
If they were identical in their actions, then lithium would be effective for epilepsy which it is not. They have similarities, but the sum of a lot of experience says that the two are usefull for different varients.
There are people who respond to one and not the other, for instance.
Linkadge
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thread:708634
URL: http://www.dr-bob.org/babble/20061129/msgs/708956.html