Posted by halcyondaze on November 25, 2006, at 8:48:24
In reply to Dopamine/Serotonin drugs..., posted by TrishP on November 25, 2006, at 8:01:42
> Ok - I think I've figured out that drugs that effect my dopamone (Wellbutrin, Abiify, etc.) give me a great sex drive, but also cause rage - regardless of the dose.
>
> SSRIs give me urinary/bladder pain.
>
> Is there a drug that I can take that will give me that happy, nice, calm, not-depressed feeling like the SSRIs, without effecting my dopamine and making me fly into a rage?
>
> Why does it have to be one or the other?
>
> Or - do I have to take both at the same time?!
>
> I'm really getting frustrated here.I have EXACTLY THE SAME PROBLEM (sort of).
All SSRIs cause my Interstitial Cystitis to flare up (bladder pain, urinary frequency/urgency), AND they all cause nocturnal enuresis (bed-wetting). For years and years, doctors just kept switching me from SSRI to SSRI. And it even happened on meds like Lamictal and Seroquel.
All drugs that affect norepinephrine cause RAGE. Desipramine, Nortriptyline ... I was a total screaming psychopath.
The one drug I can say does not cause any rage and actually "cured" my Interstitial Cystitis (while I was on it) was Parnate. I could take Ambien and Seroquel (drugs that previously caused severe bladder pain and IC symptoms to flare) and have no problems, no enuresis, no nothing.
Adderall also did this for me, but I was abusing it and taking supra-therapeutic doses.
Have you thought of trying Desipramine, which has limited DA and 5-HT effects and mostly inhibits NE? It's also a tricyclic so it has anticholinergic effects. Actually, have you tried any of the tricyclics? They're used to treat bladder pain in IC and they also have limited dopaminergic actions.
poster:halcyondaze
thread:707001
URL: http://www.dr-bob.org/babble/20061123/msgs/707010.html