Posted by Crazy Horse on November 21, 2006, at 12:33:59
In reply to An SSRI can sometimes help within one week, posted by ed_uk on November 20, 2006, at 15:12:58
> "SSRIs’ effect on depression apparent within first week
>
> Treatment with a selective serotonin reuptake inhibitor (SSRI) is associated with symptomatic improvement in depression by the end of the first week, according to a meta-analysis published in the Archives of General Psychiatry (2006;63:1217).
>
> The researchers analysed data from 28 trials involving 5,872 subjects who received an SSRI or placebo. The pattern of response seen was tested against alternative models of onset of response.
>
> The researchers found that the model that fit best was that where the incremental treatment effect was greatest in the first week, with a gradual decline in the magnitude of incremental benefits week by week.
>
> A secondary outcome indicated an increased chance of achieving a 50 per cent reduction in Hamilton Depression Rating Scale scores by one week with SSRI treatment compared with placebo (relative risk 1.64; 95 per cent confidence interval 1.2–2.25). The absolute benefits increase further with time, say the researchers, so prescribers will continue to need to wait several weeks for key treatment goals, such as remission, to be met."
>I most definitely noticed improvement in the first week when my pdoc put me on Zoloft, i thought perhaps it was placebo. It doesn't really matter..all that matters is that i felt better with-in a week of starting it.
-CH
poster:Crazy Horse
thread:705561
URL: http://www.dr-bob.org/babble/20061117/msgs/705812.html