Re: What a stupid name. » yxibow

Posted by ed_uk on November 4, 2006, at 14:31:23

In reply to Re: What a stupid name. » linkadge, posted by yxibow on November 3, 2006, at 20:54:40

Hi Yxi!
I think most doctors would be uncomfortable prescribing anything containing the antiarrhythmic drug quinidine (an isomer of quinine). Quinidine is strongly proarrhythmic and has been associated with sudden cardiac death. Although the dose of quinidine is Zenvia is very small, it's still a worry. They really ought to have found a better CYP2D6 inhibitor to use than quinidine. The purpose of the quinidine is Zenvia is solely to prolong the duration of action of dextromethorphan by inhibiting its metabolism.
Regards
Ed

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Re: What a stupid name. » yxibow ed_uk 11/4/06
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