Posted by iforgotmypassword on November 1, 2006, at 10:21:28
In reply to Re: nicotine, posted by linkadge on November 1, 2006, at 8:42:30
btw, oleamides don't potentiate 5HT-1a post-synaptic receptors do they?
>But, doesn't nicotine enhance REM sleep ?
ironically, there has been conflicting information that wellbutrin causes increased REM. It is odd. Some say it causes an increase, some say a decrease. The one's saying a decrease seemed to lump it in with other antidepressants and didn't seem to be linked to a study. (i could only read the abstract, not the refs, unless there is a way to do this on pubmed.)
this one however seems to imply less easy to understand effects:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15122973&query_hl=3&itool=pubmed_docsumthis was the one saying REM latency was reduced:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=7840365&query_hl=3&itool=pubmed_docsumnow that i read more recent ones, all others seem to note latency decrease, confusing. i guess i may be wrong.
the one on REM increase i think i read and had ingrained, after obsessively reading basically all biopsychiatry.com, way way back.
strange drug.
i still do not know how to interpret what nictonic receptor activity does. arg. and there seem to be more nictonic-type receptors than with other receptors too, right?
the idea of wellbutrin increasing REM is one of the reasons i wanted to try it (i finished a course on it once, and wondered if that mechanism is what helped, i also felt much more rested after sleep.) i was hoping a pro-muscarinic effect was involved.
poster:iforgotmypassword
thread:699037
URL: http://www.dr-bob.org/babble/20061028/msgs/699560.html