Posted by zeugma on October 30, 2006, at 16:35:11
In reply to effect of melatonin on seratonin?, posted by iforgotmypassword on October 30, 2006, at 12:52:55
Melatonin stimulates the 5-HT1A receptor, which lowers serotonin levels. 5-HT1A agonists sich as Buspar can help with melatonin-implicated disorders (such as problems with the 'internal clock' in relation to diurnal variation)by mimicking melatonin's effects. 5-HT2A receptor stimulation reversed this effect, presumably disrupting the body's internal clock. 5-HT2A agonists also reverse the antidepressant effects of melatonin in animal screens.
When serotonin, or antidepressants, are injected directly into the pineal gland, they are observed to inhibit melatonin. Luvox has an additional effect: it blocks the enzymatic degradation of melatonin in the liver, leading to greatly elevated melatonin levels and damaging levels of sleepiness. The medications considered most destructive to the synchrony of the body's internal clock with diurnal variations in light are Luvox and Haldol, and perhaps clozapine as well, and these drugs all block the metabolism of melatonin.
-z
poster:zeugma
thread:699037
URL: http://www.dr-bob.org/babble/20061028/msgs/699103.html