Posted by yxibow on October 21, 2006, at 14:18:33
In reply to Re: seroquel..., posted by linkadge on October 21, 2006, at 8:18:40
> The only think that will unveil the true likelyhood that atypical neuroleptics cause TD is time.
>
> LinkadgeClozaril, 1990. Unique agent. Almost no known reported TD cases. Unique from other atypicals in some ways. Definite EPS. Definite unpleasant side effects. "Gold standard" beyond Haldol. In the lab plus outpatient, around 19 years.
Risperdal was introduced in 1993 and so had to be in trials in 1990. 16 years. Some TD. Especially at high doses since its a chemical cousin of Haldol. Higher EPS.Zyprexa, 1996. Add a few years in trials, 13 years. Smaller amounts of TD, especially in a BJP psychiatric study of considerable amounts of patients that amalgamated it to about 1/2% per year. There has been at least a couple of new studies that have amalgamated all atypical antipsychotics (except in the elderly) to around the 2% range. Some EPS.
Seroquel, 1997, Add a few years in trials, 12 years. Minimal reports of TD, definate reports of somnolence. Lower EPS.
Yes, sometimes medications take longer to form conclusions -- old Mellaril is still out there with large QTc intervals while a campaign was staged against Geodon until it was again challenged with a 4,000 person study. I don't like the side effects with Seroquel but I take it for a particular reason. If I didn't have that reason (non psychotic in this case), I wouldn't be doing so.So atypicals basically have been around as long as SSRIs. You can take your conclusion from that as one wishes. Is a decade enough? Two? Three? If we back up two decades we're at the last benzodiazepine (except the patent extender Xanax XR). Three, around the last tricyclic.
tidings
-- Jay
poster:yxibow
thread:696107
URL: http://www.dr-bob.org/babble/20061020/msgs/696555.html