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Re: memantine-what does everyone think???

Posted by rovers95 on October 14, 2006, at 23:23:20

In reply to Re: memantine-what does everyone think???, posted by SLS on October 14, 2006, at 6:25:47

> > hi, fed up off suffering from my long term anxiety w/depression-im considering using memantine to augment lamictal (which i start next week), what do people think and what are peoples experience with memantine.....i.e. is it worth the cost!!
>
> I responded to memantine intermittently over the course of two weeks at a dosage of 20mg. I was taking Lamictal at the same time. Another person posting on PB experienced a more stable, albeit inadequate response to a low dosage of approximately 5mg. I can't recommend it, but I would not want to dissuade you from trying it either.
>
> The NIH trial showed memantine to be ineffective in treating unipolar depression. They are still studying it for bipolar depression.
>
>
> - Scott
>
>
> ---------------------------------------------
>
>
> : Am J Psychiatry. 2006 Jan;163(1):153-5.
>
> A double-blind, placebo-controlled study of memantine in the treatment of major depression.
>
> Zarate CA Jr, Singh JB, Quiroz JA, De Jesus G, Denicoff KK, Luckenbaugh DA, Manji HK, Charney DS.
>
> Mood and Anxiety Disorders Program, National Institute of Mental Health, Department of Human Health Services, Bethesda, MD, USA. zaratec@mail.nih.gov
>
> OBJECTIVE: This study was designed to assess possible antidepressant effects of memantine, a selective N-methyl-D-aspartate (NMDA) receptor antagonist in humans. METHOD: In a double-blind, placebo-controlled study, 32 subjects with major depression were randomly assigned to receive memantine (5-20 mg/day) (N=16) or placebo (N=16) for 8 weeks. Primary efficacy was assessed by performance on the Montgomery-Asberg Depression Rating Scale (MADRS). RESULTS: The linear mixed models for total MADRS scores showed no treatment effect. CONCLUSIONS: In an 8-week trial, the low-to-moderate-affinity NMDA antagonist memantine in doses of 5-20 mg/day was not effective in the treatment of major depressive


>>>Thanks scott, iv heard a mixed bag of info and seen as its side effects seem relatively mild i might as well give it a try and see what i get!!

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poster:rovers95 thread:694583
URL: http://www.dr-bob.org/babble/20061011/msgs/694898.html