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Re: VNS » snapper

Posted by SLS on October 8, 2006, at 5:59:57

In reply to VNS, posted by snapper on October 8, 2006, at 1:56:24

> Dr. said Vagus Nerve Stimulation. I am excited and somewhat tenative and hopeful, and scared all at the same time. I welcome any comments ...good or bad. I have talked to a nurse at Cyberonics in Houston and recieved a packet of info. I have researched it to a large degree on my own. I am proceeding and am going to hope for the best. I have been told that my Medicaid insurance WILL COVER IT . BRING ON THE COMMENTS AND QUESTIONS.
> THANKS
> SNAPPER
> sorry about the latent caps!!


With all of the research you have done, I am much more interested to hear what you have to say.

My impressions have been negative up until now, and I have resisted my doctor's suggestions to try it. He has no real enthusiasm for it at this point, but nothing negative to say about it either. I have a Cyberonics video that I haven't watched. It's been collecting dust for over about a year.

You take 100 TRD people, and no more than 30 respond by 12 weeks. That's a 50% or greater reduction in symptoms. Ok. That doesn't sound so great. However, the placebo rate in this population is less than 10%. 30% is actually a pretty high number. The thing is, the benefits of VNS might not become evident for 6 months. When followed over extended periods of time, some of the intial non-responders were shown to respond after 6 month and 12 month follow-up.


Two not-so-good news studies produced by a major research team in VNS demonstrated:


1. No treatment effect after 10 weeks.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16139580&query_hl=5&itool=pubmed_docsum


2. Less than 30% after 12 months

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16139581&query_hl=5&itool=pubmed_docsum


- Scott

 

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