Posted by sregan on October 6, 2006, at 18:24:54
In reply to Re: Imipramine vs. Desipramine for Melancholic Dep, posted by SLS on October 6, 2006, at 10:26:01
> For me, imipramine and nortriptyline add a mood-brightening effect that desipramine lacks. Desipramine is energizing and alerting, but might lack something in the way of allowing you to feel good about doing things, motivation, interest, and reducing anhedonia. Perhaps this has something to do with its lack of serotonin reuptake inhibition. I prefer the way I feel on nortriptyline. I currently take 100mg. Remember, though, this is just the way I react to these drugs. Everyone is different.
Very true. I was interested in imipramine or amitriptyline because I've read both can reset the HPA over time (not as dramatic as RU486 or even what I've read about mirtazapine/remeron). I had a period of about 6 months of extreme stress (most stressful period of my life) and haven't recovered. From my research lately indicates my HPA is out of whack. My salivary cortisol was high at 8am then on the low end of the scale the other three testing times. I believe I'm dealing with Melancholic depression as I always feel pretty normal by the end of the day except on the days I was experimenting with licorice and I felt crummy into the late evening (extended cortisol?).
I thought I read that NE and cortisol have a see saw relationship. If cortisol is high then NE must be low? I'm wondering if low NE is causing my AM anxiety/dysphoria?
poster:sregan
thread:692126
URL: http://www.dr-bob.org/babble/20061003/msgs/692498.html