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Atypicals vs old-school meds...

Posted by med_empowered on October 6, 2006, at 11:03:06

In reply to Re: accessing amisulpride in canada » ed_uk, posted by Phillipa on October 5, 2006, at 22:35:13

really, all I think this study "proves" is what we've already known: the 2nd generation meds are over-hyped. They're still D2 blockers, afterall, so you're still going to get side effects.

Plus, in the US at least, there was a tendency to way, way, waaaay overprescribe the neuroleptics, both in terms of patient selection (Thorazine for "hyperkinetic" children, for instance) and in terms of dosage (20mgs of Haldol was pretty standard for a long time). So...when the new drugs came out, of course they looked good up against mind-numbing dosages of old-school drugs. I imagine that 10mgs of zyprexa compared to, say, 200mgs of Thorazine wouldn't look nearly so good. Plus, with the built-in serotonin antagonism, you might be suppressing TD and acute EPS more effectively than with other meds (note that Mellaril had low EPS in part b/c of its effects on serotonin; it still caused TD).


I really don't see why we still use neuroleptics. I mean, the whole dopamine theory of schizophrenia is pretty much crap, so why cant docs and drug companies move on?


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URL: http://www.dr-bob.org/babble/20061003/msgs/692389.html