Posted by psychobot5000 on September 17, 2006, at 12:41:48
In reply to Re: lamictal and dopamine, posted by blueberry on September 15, 2006, at 17:48:26
> The first day I tried lamictal at just 12.5mg was incredible. Two hours after I took it I got a clear amphetamine rush with goosebumps and everything. I mean, I felt high and I felt absolutely great. It was without a doubt in my mind a dopamine feeling. It was clearly dopaminergic. I develope tolerance the good effects of dopamine super fast though, so the goodness did not last but a couple days, and then all I had left was some extreme nervousness and anxiety which also felt dopaminergic.
It seems hard to find good information on what lamotrigine's pharmacalogical effects actually are, but I had a similar experience--clearly improved mood, following the first dose, or any raised dose, followed by what seemed like down-regulation or compensation...all I know is that the positive effects disappeared, and I was left with a bit of cognitive slowing and sleepiness. Disappointing in the extreme.It seemed vaguely dopaminergic to me, but I have no evidence that that is actually the case. I have been trying to figure out what the antidepressant mechanism of action is for Lamictal, so as to find another med with similar workings, with little success.
poster:psychobot5000
thread:686011
URL: http://www.dr-bob.org/babble/20060909/msgs/686813.html