Posted by notfred on September 16, 2006, at 0:20:12
In reply to Re: What works on norepinephrine? possibly only ho » notfred, posted by SLS on September 15, 2006, at 7:28:01
> Hi.
>
> Nice post.thanks !
>
> Do you have a comprehensive list of medications compiled?For selfish reasons (norepinephrine effecting AD's
seem to be the only ones that work for me) I don't
have a comprehensive list of all AD's. SSRI's (all of them) have failed to do anything, even at high doses.Over the last 20 years my sucesses have been:
Imipramine & therefor Desipramine (horrid sweating) Nortriptyline & Protriptyline
Doxepin, which was my mainstay AD as I liked its sedating, anticolanergic & anithistimitic effects.After 10 yrs Doxepin pooped out, caused flat effect, & other TCA's were no better. MAOI's caused hypertensive events, I seem very sensitive to this. Otherwise they were very effective. Trazodone at high doses (300 mgs) worked but I never woke up.
Effexor + Doxepin + Dexedrine, Atavin prn, was very effective for several years. I dropped the Doxepin for Remeron, seeking less flat effect. Success with this until Effexor started causing arterial hypertension (140/95 to 140/105). Dexedrine was also a minor player in causing
the hypertension.Dropped Effexor and Dexedrine for Wellbrutrin,
hypertension ended. Effective but I felt "less than well" 80-90 % better but apathty was an issue. Weight gain leading to pre diabetes II. Ativan prn.Started seeing a top psycopharmacologist & identified the Remeron as causing weight gain and
apathty. Dropped Remeron for Lunesta, added Provigil. Lost 20 lbs, diabetes resolved, A1C lowered to normal range.Presently I am on Wellbrutrin (300 mgs), Provigil
(400 mgs), Lunesta (6 mgs), and Ativan (1-2 mgs/day prn). This combo is the best yet, no side effects provided I do not take Provigil w/o having a small snack every 4 hrs. Ativan will cause some memory problems if I take it for more than 3 days in a row but excessive stress will cause me to crash so the trade off is worth it if I need to take Ativan every day. I do not find I take more
Ativan today than I did 15 yrs ago.For me the key to more than 20 yrs of remission
are a norepinephrine effecting AD, stress control,
and good restorative sleep. I have had a few breakthrough depressions, which resolve with a dosage adjustment of the AD, better control of stress and sleep, or poop out indicating it is time to try a new AD. I keep a short list of AD's to try next. It helps that I do not give a hoot if I take meds.
poster:notfred
thread:686094
URL: http://www.dr-bob.org/babble/20060909/msgs/686419.html