Posted by notfred on September 12, 2006, at 0:44:10
In reply to Dexamethasone effect on cortisol???Raise/lower?, posted by Jimmyboy on September 11, 2006, at 17:36:04
> Anyone know if taking dexamethasone raises or lowers your cortisol level?
cortisol is hydrocortisone, dexamethasone is a
40X more potent form of cortisol.Your body stops making cortisol as you just added
some dexamethasone. The amount of circulating cortisol remains up till the dexamethasone is metabolized and cortisol levels drop off. Then the
body starts making cortisol.A shot of Dexamethasone is likely to give you higher levels of cortisol, it sure feels that way.
> "If short-term, high-dose dexamethasone treatment proves to have antidepressant effects, how might this be reconciled with antiglucocorticoids having similar effects?Long term use of steroids at a level that supresses the bodies production of cortisol
carries a high risk for loss of bone and damage to optic nerve, just to name a few. Some people have psychotic reactions to taking any corticoids and many do if they take them long enough.I take prednisone (4X cortisol) from time to time, it does have mood elevating effects. It also has "snap peoples heads off at the drop of a hat" effects. I don't find short term high doses have any effect on long term mood.
poster:notfred
thread:685086
URL: http://www.dr-bob.org/babble/20060909/msgs/685177.html