Posted by linkadge on September 8, 2006, at 6:45:19
In reply to Re: Does anti-psychotics help, or worsen, OCD?, posted by SLS on September 8, 2006, at 5:48:00
I think its hard to say. Some researchers conclude that the antiobsessional qualities of the SSRI's are dependant upon stimulation of 5-ht2a/c receptors. I think the reason being, is that these receptors activate the parietal lobes which are often hypofunctional in OCD, and dampen the frontal cortex, which is overactive in OCD.
These receptors modulate gabaergic currents in the frontal cortex. 5-ht2a/c stimulation dampens hyperactive prefrontal cortex activity.
There are a few case reports of mescaline a 5-ht2a/c agonist, being of use in treatment resistant OCD.
The point I'm getting to, is that some of the newer antipsychotics block these receptors, and could (at least in theory) block some of the anti OCD properties of the SSRI's. OTOH, these agents also block certain dopamine receptors, which may convey anti-OCD properties.
So it could depend on the patient, but it could go either way.
Linkadge
poster:linkadge
thread:684141
URL: http://www.dr-bob.org/babble/20060901/msgs/684181.html