Posted by yxibow on September 8, 2006, at 2:02:36
In reply to Re: I wonder about dopamine agonists, posted by willyee on September 7, 2006, at 10:58:38
> > I wonder why dopamine agonists usually cause sedation. It seems like anything that is pro-dopamine would be stimulating. I wonder what mechanism is at play that causes dopamine agonists to be sedating. Maybe they slow down the release of actual dopamine? Dunno.
>
> Yeah without being able to be technical,i have read over and over these two things,
>
> --Dopamine can be both stimulative as well as inhibitory.
>
> -- Gaba can be sedating,as well as stimulative.Too much gaba can greatly increase anxiety.
>
> Makes finding help a lot easier eh,stinks.
The manipulation of GABA can be anxiolytic, sedating -- but can also in too much amounts cause seizures rather than protect against them, which was and is the one of the many uses of benzodiazepines, and the more refined AED drugs that followed them.
Dopamine agonists such as carbidopa-levidopa (Sinemet/CR), primary treatment agents in Parkinson's, can even in an effective dosage range, produce psychosis. This is not surprising given the dopamine model of psychosis in schizophreniform disorders. Often patients have to take an amount of Seroquel (the agent with the least effect at D2 and pseudoparkinsonism outside of clozaril which may also be necessary as it has an even lower potential of D2 activity but requires expensive blood monitoring for low white blood cell count [2% mandatory discontinuation typical] and unpleasant side effects.)
poster:yxibow
thread:683752
URL: http://www.dr-bob.org/babble/20060901/msgs/684162.html