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Re: Would a D2 agonist make an AP inefficient?

Posted by SLS on August 21, 2006, at 10:15:52

In reply to Would a D2 agonist make an AP inefficient?, posted by flip_flop on August 20, 2006, at 3:47:59

> Since amisulpride, an antipsychotic, can cause elevated prolactin levels, would adding a D2 agonist (to normalize prolactin levels) cause the antipsychotic effects from amisulpride to diminish? Amisulpride has high affinity for D2 and D3 receptors.

APs are sometimes given to Parkinsons patients who have developed psychosis during treatment with DA agonists. Unfortunately, with the exceptions of clozapine and possibly quetiapine, they often worsen motor symptoms. Both quetiapine and clozapine have very low affinities for D2 receptors and can still be effective as a treatment in this situation. This might indicate that these drugs still exert antipsychotic effects in the presence of DA agonists.


- Scott

 

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