Posted by Check on August 14, 2006, at 18:23:26
I am currently thinking about trying an MAOI for my treatment-resistant, atypical depression and I am wondering if anyone has any advice as to which one would be best. I have tried lexapro, zoloft, wellbutrin, cymbalta, adderall, and effexor to no avail. I am nervous and depressed most of the day and have obsessive tendencies. So far (correct me if I'm wrong) it seems that:
Nardil has the best reputation for one such as myself, but since it was reformulated in 03 there are doubts about its efficacy. It also is the most sedating MAOI but the best for social anxiety (which I have). I have also read that its hydrazine group makes it very hard on the liver.
Parnate is metabolized into amphetamine and is the most activating of the MAOIs. It doesn't cause weight gain, but can cause agitation and is the touchiest about tyramine rxns.
Marplan seems to be the middle of the road drug lacking the more extreme pros and cons of the other two.
I've read a little about moclobemide and selegline, but they don't seem to pack the same punch as the older MAOIs. So far I'm thinking about marplan. Any advice would be much appreciated.
Thanks
poster:Check
thread:676429
URL: http://www.dr-bob.org/babble/20060810/msgs/676429.html