Posted by SLS on August 12, 2006, at 12:20:43
In reply to Re: Emsam Day 14 - Too soon to tell if it's workin » SLS, posted by Jost on August 12, 2006, at 11:59:07
> I hope not. Is the foreboding a learned response, or an actual response, to each different AD, do you think?
A few antidepressants - not all - produce a worsening of my depression. However, they don't all produce the same kind of worsening. Many antidepressants produce an improvement. Unfortunately, they rarely last more than three days.
> Wonder why you would get so much down-regulation. Have you researched how or what might cause re-upregulation, or might conteract down-regulation?
I think it might be something that happens postsynaptically along the second messenger / gene expression cascade. It must have a memory of some sort. This might be where the mechanisms lie that set up the phenomenon whereby subsequent exposure to a previously effect drug yields non-response.
Just musing. I really have very little idea what's going on.
- Scott
poster:SLS
thread:675598
URL: http://www.dr-bob.org/babble/20060810/msgs/675835.html