Posted by SLS on August 10, 2006, at 19:50:04
In reply to Re: Safe to Combine Selegiline/Remeron?, posted by linkadge on August 10, 2006, at 17:05:21
> Taken from www.rxlist.com
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> "These studies have shown that mirtazapine acts as an antagonist at central presynaptic a2 adrenergic inhibitory autoreceptors and heteroreceptors, an action that is postulated to result in an increase in central noradrenergic and serotonergic activity."
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> But, I read from some other source, that there was a co-release of dopamine (in certain areas of the brain) after blocade of these receptors. I could be mistaken though.
You are not mistaken. I read the same thing. However, I was interested in the mechanism by which this occurred since the drug I'm taking, sibutramine, has been reported to force an accelerated downregulation of NE alpha-2 receptors. It would be nice if it were to promote an increase in the release of dopamine this way.
- Scott
poster:SLS
thread:673727
URL: http://www.dr-bob.org/babble/20060810/msgs/675505.html