Posted by silvercoin on August 9, 2006, at 16:50:17
In reply to What is wrong with my brain???, posted by OddlyAnhedonic on August 9, 2006, at 11:56:55
> I've been a luker on these boards for seven or eight years...finally decided to post my first question...
>
> I've been a life long atypical depressive and severe anhedonic. Finally got treated with Paxil a few years ago and am doing okay with the depression. But still experiencing no pleasure in life. My doctors often shake their heads in confusion as they see how my head reacts to various treatments and events. So I am coming here hoping to get some clues as to why my head is so weird. So here are some datapoints:
>
> First off, I am immune to the euphoric effects of cocaine. NOBODY believes me when I say this. But it is absolutely true. I tried it many times - before and after I got medicated for depression - and all it does it increase my blood pressure and empty my wallet. Tastes bad. No euphoria. No increased energy. Nada. I'm not complaining...but it is obviously an anomolous reaction.
>
> Same for Wellbutrin. Tried it as my first anti-depressent. Only made me twitch and grind my teeth. No antidepressent effect even at very high doses.
>
> I *do* like ephedrine. It makes me feel almost "normal"...no jitters. Not exactly euphoric, but I feel like I am not walking through life wearing ten ton shoes. But sadly, ephedrine is very dangerous so I don't take it.
>
> Paxil does relieve my depression - but only in high doses (40mg per day).
>
> So there ya go. Any theories or wild guesses are appreciated. I'll also offer any more data I can. Just ask. This seems like a great forum. I hope I can maybe find some answers here.
If ephedrine has therapeutic value, it might pay to try something that is more noradrenergic, such as Effexor, Cymbalta, or desipramine. In particular, desipramine might be a good one to try as it is rather activating.Todd
poster:silvercoin
thread:675188
URL: http://www.dr-bob.org/babble/20060802/msgs/675241.html