Posted by sanshin on July 9, 2006, at 1:15:49
In reply to Re: Moving from Nardil to Emsam. » sanshin, posted by Questionmark on July 8, 2006, at 22:58:44
Thanks for the thoughtful considerate post.
That's an interesting conjecture; someone doing well with Nardil may not do as well with selegeline or Parnate.
My pdoc seems willing to do a little prescribe and pray by exploring some combo of Emsam and Nardil. I'll post whatever result I might have.
Note to file: I am ramped back up on 75 mg a day of phenelzine. It was another accelerated med change as I dropped Emsam, peeled the last patch away and went back to the red Nardil pills.
I did not give Emsam enough time to draw fair conclusions. Just too much depr and anxiety during the changeover.
+++++++++++++++++++++++++++++++++++Nardil is significantly more serotonergic (and less catecholaminergic) than selegeline/Emsam, and you may be having extremely reduced serotonin transmission and a possible catecholamine overload (esp dopamine?), which can make your emotions much more unstable and sensitive and can result in a return of depression. Can you try some 5-HTP (or, possibly even better, tryptophan [if you can get it]) along with it? I would try this. And/or try to get some tryptophan. (Under your doctor's supervision, preferably, of course.)
> If he/she would be willing, maybe you could even maintain low doses of Nardil and Emsam, while gradually reducing the former and raising the latter. However, my personal theory is that those who do well with Nardil will not do as well with Parnate or selegeline, and vice versa. But hopefully I'm wrong about this.
> In any case, good luck.
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poster:sanshin
thread:663682
URL: http://www.dr-bob.org/babble/20060701/msgs/665323.html