Posted by zeugma on June 27, 2006, at 6:07:45
In reply to Re: Klonopins relationship to serotonin » SLS, posted by zeugma on June 12, 2006, at 18:12:19
L-glutamic acid...improves... other functions associated with the frontal lobes. It imporves insight into one's condition (reduces symptoms of anosognia), improves the sense of humor [!]>>
apparently I was right about modafinil:
Sleep. 2006 Jun 1;29(6):841-7.
The effects of caffeine, dextroamphetamine, and modafinil on humor appreciation during sleep deprivation.
Killgore WD, McBride SA, Killgore DB, Balkin TJ.
Division of Neuroscience, Department of Behavioral Biology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA. william.d.killgore@us.army.milSTUDY OBJECTIVES: Sleep loss consistently impairs performance on measures of alertness, vigilance, and response speed, but its effects on higher-order executive functions are not well delineated. Similarly, whereas deficits in arousal and vigilance can be temporarily countered by the use of several different stimulant medications, it is not clear how these compounds affect complex cognitive processes in sleep-deprived individuals. DESIGN: We evaluated the effects of double-blind administration of 3 stimulant medications or placebo on the ability to appreciate humor in visual (cartoons) or verbal (headlines) stimuli presented on a computer screen following 49.5 hours of sleep deprivation. SETTING: In-residence sleep-laboratory facility at the Walter Reed Army Institute of Research. PARTICIPANTS: Fifty-four healthy adults (29 men, 24 women), ranging in age from 18 to 36 years. INTERVENTIONS: Each participant was randomly assigned to 1 of 3 stimulant medication groups, including caffeine, 600 mg, n = 12; modafinil, 400 mg, n = 11; dextroamphetamine, 20 mg, n = 16; or placebo, n = 14. MEASUREMENTS AND RESULTS: Humor appreciation for cartoon stimuli was enhanced by modafinil relative to both placebo and caffeine, but there was no effect of any stimulant medication on the appreciation of verbal humor during sleep loss. In contrast, all 3 stimulants improved psychomotor response speed, whereas only caffeine and dextroamphetamine improved ratings of subjective sleepiness. CONCLUSIONS: Findings suggest that, despite similar alerting and vigilance-promoting effects, these 3 compounds have significantly different effects on those highly complex cognitive abilities mediated by the pre-frontal cortex.>>
I can't believe anyone actually did this study. Subjective sleepiness is no fun though
-z
poster:zeugma
thread:654917
URL: http://www.dr-bob.org/babble/20060623/msgs/661802.html