Posted by zero on June 20, 2006, at 11:07:52
In reply to Re: EMSAM - Day #1 (6/13/06) » zero, posted by Phillipa on June 19, 2006, at 13:14:14
Dear Phillipa,
I suspect your "speed" reference is pretty accurate. See this excerpt from EMSAM's PDR entry:
"In vivo Metabolism
Transdermally absorbed selegiline (via EMSAM) is not metabolized in human skin and does not undergo extensive first-pass metabolism. Selegiline is extensively metabolized by several CYP450dependent enzyme systems (see In vitro Metabolism). Selegiline is metabolized initially via N-dealkylation or N-depropargylation to form N-desmethylselegiline or R-(-) methamphetamine, respectively. Both of these metabolites can be further metabolized to R-(-)amphetamine. These metabolites are all levorotatory (l-) enantiomers and no racemic biotransformation to the dextrorotatory form (i.e., S(+)-amphetamine or S(+)-methamphetamine) occurs. R(-)-methamphetamine and R(-)amphetamine are mainly excreted unchanged in urine. ".
zero
poster:zero
thread:658676
URL: http://www.dr-bob.org/babble/20060617/msgs/659166.html