Posted by pseudoname on June 16, 2006, at 9:42:48
In reply to Re: buprenorphine and cognition » pseudoname, posted by Phillipa on June 15, 2006, at 20:39:23
Hi, Phillipa.
> Does it act an opiod in your body. Usually kind of help you feel good?
For me, at the doses I've tried it (up to 5 mg/day), buprenorphine doesn't produce any high or buzz. It doesn't even make me feel as good as caffeine can. Its benefit for me seems to be that those persistent, intense, hostile thoughts and feelings just stop.
(As they did this morning at *half* the dose I used yesterday!)
:-)Buprenorphine weakly activates some of the typical euphoric/analgesic opioid receptors, but it also BLOCKS kappa-opioid receptors that trigger dysphoria. I wonder if that kappa-blocking is mostly or entirely responsible for its antidepressant effect in me.
AFAIK, there are no selective kappa antagonists on the market yet, but I guess research is being done. I'd like to try them when they come out.
• “Kappa Opioid Antagonists: Past Successes and Future Prospects” by Matthew D Metcalf & Andrew Coop. AAPS Journal. 2005; 7(3): E704-E722 http://www.aapsj.org/view.asp?art=aapsj070371
poster:pseudoname
thread:657263
URL: http://www.dr-bob.org/babble/20060610/msgs/657558.html