Posted by yxibow on June 13, 2006, at 18:37:15
In reply to Re: labwork for antipsychotics » xbunny, posted by ed_uk on June 12, 2006, at 13:30:35
> Hi Buns
>
> A prolonged QT interval is associated with an abnormal heart rhythm called torsades de points. It can occasionally lead to sudden death. The risk was particularly high with thioridazine (Mellaril), which is why it was discontinued.
>
> EdBranded Mellaril was discontinued by Novartis to cover their ***. ANDAs continue in the US for generic companies for Thioridazine which does pose a higher risk of QTc intervals. You can see which generic companies are marketing on Costco's site for example (MYL), Mylan.
Geodon, which originally was linked to a very small percentage of them and was discontinued, a new NDA was resubmitted and approved after a post-marketing Phase III study of 4000 patients on Geodon which showed no prolongation.
poster:yxibow
thread:655086
URL: http://www.dr-bob.org/babble/20060610/msgs/656552.html