Posted by Jakeman on June 11, 2006, at 20:10:34
In reply to EMSAM doses too low to effect depression ?, posted by notfred on June 11, 2006, at 13:24:36
I don't know if EMSAM inhibits MAO-A. Perhaps at the higher doses? Maybe some of our MAOI experts can chime in. According to their studies it has efficacy for major depression even at the lowest dose.
warm regards, Jake
> Deprenyl and EMSAM contain the same active ingredient. The doses for depression are far higher that those mentioned on this board.
> I have read that you need MAO A inhibition
> to be an effective AD. That would explain
> why the higer doses of Deprenyl/EMSAM are needed, as they also inhibit MAO A at higer doses.
>
> /quote
>
> The clinical potential of Deprenyl in neurologic and psychiatric disorders
>
> Journal of Neural Transmission, Supplement (Austria), 1996, -/48 (85-93)
>
>
> This article reviews the results of clinical studies with Deprenyl in various neurologic and psychiatric disorders except Parkinson's disease. Promising results could be observed both in narcolepsy in a dose of at least 20 mg/day in three different trials and in one study of Tourette's syndrome including attention hyperactivity disorders using an average dosis of 8.1 mg/day. Controversial results were reported for Alzheimer's disease. On the one hand significant improvement of cognitive functions was found by various authors. On the other hand in a more recent study no effect on the progression of the disease could be observed.
>
> For depression a higher dosage of deprenyl between 30 to 60 mg/day appears to be necessary for effective treatment.
>
> No positive results were found in amyotrophic lateral sclerosis and in tardive dyskinesias.
>
>
poster:Jakeman
thread:655515
URL: http://www.dr-bob.org/babble/20060610/msgs/655688.html