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Re: Klonopin Mechanisms? » blueberry

Posted by yxibow on June 10, 2006, at 0:46:15

In reply to Klonopin Mechanisms?, posted by blueberry on June 9, 2006, at 15:53:08

> Other than working on GABA, what else does klonopin do? I have heard that it affects serotonin receptors, but I don't know which ones or how it affects them. Not sure how it might affect dopamine or norepinephrine other than dampening them down or slowing their release. Just guessing. Any detailed info on klono mechanisms?


All benzodiazepines work on the 3 subreceptors of GABA, anxiolytic, sedative-hypnotic, and anticonvulsant, in varying degrees -- i.e. Halcion would be primarily sedative-hypnotic while Valium would be more anxiolytic but would cover the other receptors as well.


In the most sensitive patients there may be some minor effects on other transmitters but they are not normally used that I know of for anything else other than their effect on GABA and their safety profile compared to barbiturates.


The only other effects that they may have in some people to cause depression really probably primarily comes from a general sense of CNS depression and not from transmitters I would think.

 

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