Posted by SLS on May 30, 2006, at 8:22:29
In reply to Re: hint on last thread (SLS?) » SLS, posted by idolamine on May 29, 2006, at 19:56:33
> Thanks for the response scott. Aren't the levo isomers inactive anyway?
I think they have weak actions at the DA transporter, but I may be wrong. Anyway, the amount of metabolite resulting from the Emsam patch is much reduced compared to oral delivery. I was thinking that you might be allergic to amphetamine. That might be far-fetched. I don't know.
How would you describe your experience with hyperkinesia?
> I'm at a quandry- I wonder if I should start serzone again- but if I stay on the selegeline, in your personal opinion, could it down-regulate DA receptors after awile? Thanks
It is reasonable to think that it would. Selegiline increases the levels of extracellular dopamine. I don't think the mechanisms involved in producing this increase are well understood, but they might be separate from MAO inhibition. To expose the postsynaptic membrane with the increased concentration of dopamine could produce a downregulation of DA receptors. This should occur after two weeks.
- Scott>
>
> > > these same syptoms occured once I escalated my dose of adderall, in the past. Even after long-term cessation of adderall, I still get hyperkinesia. Could this be related to selegeline?
> >
> > I really don't know.
> >
> > Selegiline is metabolized into L-amphetamine and L-methamphetamine. Their biological activities at therapeutic dosages are considered to be weak, though. Nonetheless, you might be sensitive to amphetamines and/or their effects on catecholamines.
> >
> > I have no idea what the course of these side effects are. I don't know whether or not they disappear with continued use.
> >
> > Hopefully, someone here will have more insight into your reaction to theses drugs. It almost sounds as if your dopamine receptors are too sensitive.
> >
> > Sorry I couldn't be of more help.
> >
> >
> > - Scott
> >
> >
>
>
poster:SLS
thread:650135
URL: http://www.dr-bob.org/babble/20060530/msgs/650367.html