Posted by RobertDavid on May 22, 2006, at 23:24:07
In reply to Emsam and insomnia, posted by Jakeman on May 22, 2006, at 19:28:57
> I know nothing about the half life of this drug and the transdermal method of delivery.
>
> I wonder how one might arrange peak effects to occur in daytime. Is it feasible to put on the patch first thing in morning then take it off around 4 or 5 pm? Would that help with any night-time agitation? Any comments appreciated.
>
> warm regards, JakeJake:
I have always suffered from insomnia. EMSAM is activating and hasn't improved my sleeping.
But in looking for ways to improve my sleep my doctor recomended I take off the patch before bedtime and put it back on in the morning which did help. Your basically wearing it 16 hours and off 8. Selegiline has a short half life so you can get away with it.
I had suspected that I was getting more selegiline than I needed. I mean I really felt good, noticable increase in energy all positives, but with the 24 hour delivery even at the 20mg dose it was continuing strong through the night. And since the increase in energy was so noticable I wished I had an option to try taking a slightly lower dose.
So I contacted a reasercher from the EMSAM studies and discussed if the patch could be cut (you can read from my above post about it if you like) and though the packaging says do not cut it, he indicated you can without issue, in fact that's what they did with test animals.
Anyway, I cut it in half this morning and felt very good today. I'm planning on wearing my new "10mg patch" 24/7 and hope I sleep better while getting the dose necessary for me to get the benefits I want. We'll see.
I'm not sure what your primary disorter is, but mine is SAD and GAD with mild depression. I'm hoping that my new smaller dose will be enough to continue to keep my mood up, give me the energy I like and to offset the mental fog I get from klonopin (which treats my anxiety). I would suspect those with major depression will need higher doses, 10mgs would not be enough. In the studies 7% of the patients reported insomnia.
Anyway, a couple options for you to think about. Otherwise you could always take something with it until your body hopefully adjusts to it like Lunesta or even Seroquel (which will probably knock you out).
Good luck
Rob
poster:RobertDavid
thread:647080
URL: http://www.dr-bob.org/babble/20060520/msgs/647173.html