Posted by Donna Louise on May 8, 2006, at 20:45:06
In reply to Triptans and MAOIs » Donna Louise, posted by ed_uk on May 8, 2006, at 12:56:19
> Hi
>
> Here is some useful information by Stewart J. Tepper, MD...........
>
> Triptans and MAOIs
>
> The enzyme monoamine oxidase (MAO) breaks down some or all of four triptans: almotriptan (Axert), rizatriptan (Maxalt), sumatriptan (Imitrex), and zolmitriptan (Zomig). At the same time, some antidepressants can be used as anti-migraine drugs and work by inhibiting MAO (MAOIs). These MAOI antidepressants include isocarboxazid (Marplan), phenelzine (Nardil), and tranylcypromine (Parnate). If you are taking one of these drugs, it inhibits the very enzyme your body needs to break down certain triptans.
>
> As a result, the FDA recommends not using three triptans with MAOIs: rizatriptan (Maxalt), sumatriptan (Imitrex), and zolmitriptan (Zomig). Instead, it seems prudent to use triptans that are not broken down by MAO: eletriptan (Relpax), frovatriptan (Frova), and naratriptan (Amerge). Another option is almotriptan (Axert). Because almotriptan can be eliminated in several ways, its interaction with an MAOI is not of consequence.
>
> Edoh thank you thank you, I can't thank you enough. This info goes straight to the pdoc. Shouldn't they know?? I think mine at least knows that an MAOI can help. Maybe with more time this patch I am now on will solve the problem but in the meantime I am getting one of these pronto.
Donna
poster:Donna Louise
thread:641231
URL: http://www.dr-bob.org/babble/20060504/msgs/641549.html