Posted by ed_uk on May 3, 2006, at 9:14:15
In reply to Aprepitant, posted by TJO on May 3, 2006, at 6:05:09
Hi Tam,
>Is it out yet?
Yes, but not as an antidepressant. It's available as an antiemetic to prevent nausea and vomiting caused by cancer chemotherapy.
Here is some information.....
'Aprepitant is a neurokinin-1 (NK-1)-receptor antagonist (substance P antagonist)'
'Aprepitant was in Phase II studies expected to be an effective antidepressant, but Phase III studies failed to show efficacy in the treatment of depression. Aprepitant's failure in depression sounds a warning for substance P antagonists - it is not the first drug in this class to be suspended from trials in depression.'
Regards
Ed
poster:ed_uk
thread:639531
URL: http://www.dr-bob.org/babble/20060429/msgs/639553.html