Posted by pseudoname on April 26, 2006, at 18:01:40
In reply to Emrich on buprenorphine (Lancet 1982), posted by pseudoname on April 22, 2006, at 15:14:50
Some day I have to collect all this stuff together on a web site. But here are the links.
For anyone considering bupe, I think these may be good pages to show your doc. I hope he/she won't think a special DEA waiver is needed to Rx it for depression. (It isn't. I put several posts explaining bupe law and how to keep prescribers out of trouble – starting here: http://www.dr-bob.org/babble/20051031/msgs/573784.html.)
When you first start, do NOT take more than 0.1 or 0.2mg a day. Be prepared for mild nausea & dizziness for only 1-2 days. Larry Hoover gave me advice on taking such small doses with 2mg tablets: http://www.dr-bob.org/babble/subs/20051106/msgs/580668.html
The main bupe-for-depression reference is this:
• J. Alexander Bodkin, MD, Gwen L. Zornberg, MD, Scott E. Lukas, PhD, and Jonathan O. Cole, MD. "Buprenorphine Treatment of Refractory Depression." Journal of Clinical Psychopharmacology, 1995, 15, pp. 49-57 http://balder.prohosting.com/~adhpage/bupe.htmlAnd this editorial explains why bupe isn't used more for depression, despite its effectiveness:
• Enoch Callaway. "Buprenorphine for Depression: The Un-adoptable Orphan [Editorial]." Biological Psychiatry. 1996 Jun 15; 39(12):989-90. http://www.dr-bob.org/babble/20010625/msgs/67856.htmlMy diary of my first few months on bupe starts here, including Ed_UK's advice about side effects (like constipation): http://www.dr-bob.org/babble/20051112/msgs/579345.html
poster:pseudoname
thread:635895
URL: http://www.dr-bob.org/babble/20060423/msgs/637285.html