Posted by MARTY on April 16, 2006, at 14:38:08
In reply to Re: Nardil Euphoria MalcolmS, posted by linkadge on April 16, 2006, at 12:40:44
Hmm okay, so if I have some anticholinergic at home I could try a small dose to see if it help with my MAOI (Nardil) withdrawal ? I though about trying that. I may try it and come back tell my experience results.Marty
> Hmm, I know that anticholinergics are sometimes used to lessen the withdrawl from antidepressants.
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> A lot of antidepressants are functional anticholinergics. There is a serotoninergic/cholinergic axis, noradrenergic/cholinergic axis, dopaminergic/cholinergic axis.
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> So when you increase the monoamines, you are suppressing cholinergic function in certain ways. Discontinuation often involves a rebound in the cholinergic function, which can cause all sorts of reactions, so you may be able to reduce withdrawl by using an anticholinergic.
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> That is one take on it. I know anticholinergics are used to reduce TCA withdrawl.
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> The TCA's can do a double whammy on supressing cholinergic function. The molecules themselves are anticholinergics, but when combined with increase in noradrenaline, I would assume the axis gets a strong shift. That is one theory about depression is that it is an imballence in the choliergic/adrenergic axis, and that drugs can try and pull it more in the favor of noradrenergic dominance.
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> Linkadge
poster:MARTY
thread:632925
URL: http://www.dr-bob.org/babble/20060412/msgs/633870.html