Posted by RobertDavid on April 10, 2006, at 15:48:38
In reply to Doseage Question, posted by Declan on April 10, 2006, at 15:18:44
> The patches have names like the 20mg patch and so on. Does this tell you anything about the daily dose of selegeline that you absorb? Does it mean you absorb 20mg/d?
> The patches have names like the 20mg patch and so on. Does this tell you anything about the daily dose of selegeline that you absorb? Does it mean you absorb 20mg/d?
Perhaps this info from the BMS website will answer your question, I still dont'completely understand it:EMSAM® (selegiline transdermal system) is a transdermally administered antidepressant. When applied to intact skin, EMSAM is designed to continuously deliver selegiline over a 24-hour period.
EMSAM systems are transdermal patches that contain 1 mg of selegiline per cm2 and deliver approximately 0.3 mg of selegiline per cm2 over 24 hours. EMSAM systems are available in three sizes: 20 mg/20 cm2,30 mg/30 cm2, and 40 mg/40 cm2 that deliver, on average, doses of 6 mg, 9 mg or 12 mg, respectively, of
selegiline over 24 hours.Absorption
Following dermal application of EMSAM to humans, 25%-30% of the selegiline content on average is delivered systemically over 24 hours (range ~ 10%-40%). Consequently, the degree of drug absorption may be 1/3 higher than the average amounts of 6 to 12 mg per 24 hours. Transdermal dosing results in substantially higher exposure to selegiline and lower exposure to metabolites compared to oral dosing, where extensive first-pass
metabolism occurs (Figure 2). In a 10-day study with EMSAM administered to normal volunteers, steady-state selegiline plasma concentrations were achieved within five days of daily dosing. Absorption of selegiline is similar when EMSAM is applied to the upper torso or upper thigh.
poster:RobertDavid
thread:630549
URL: http://www.dr-bob.org/babble/20060408/msgs/631469.html