Posted by SLS on March 18, 2006, at 10:21:19
In reply to Re: Never thought I'd hear this....., posted by linkadge on March 18, 2006, at 9:40:22
> MANJI: Everything I said about antidepressants would apply to stimulants and maybe even more so. Enough stimulants seem to be capable of triggering manic-like episodes in anyone. In the lab, most of our animal models of mania are based on using stimulants. That is to say, we use repeated amphetamine administration to make the animal become sensitized so it shows high degrees of motor activity and hedonic [pleasure-seeking] behavior.
>
> Interestingly, you can prevent this manic response to stimulants by pre-treating the animal with lithium. This is how we model human mania for our animal experiments. So if we have a new biochemical pathway that may work, one of the models we use is to treat animals with stimulants to make them hyperactive and then use this drug.
I stand corrected!I still think the majority of manic reactions to antidepressants indicates bipolar diathesis.
I respect Dr. Manji enough to give him the last word. :-)
To be continued...
- Scott
poster:SLS
thread:620137
URL: http://www.dr-bob.org/babble/20060315/msgs/621630.html