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Re: Scared to start the Parnate » Maxime

Posted by jedi on March 18, 2006, at 1:45:10

In reply to Scared to start the Parnate, posted by Maxime on March 17, 2006, at 16:48:19

> Hi
>
> I saw my pdoc today and told him I stopped the Prozac. He wants me to start the Parnate NEXT WEEK. Prozac stays in your system for 5 weeks. When I mentioned this to him he said that the rules are often too strigent and that I should try just 10 mg next week. Even with other SSRIs you are suppose to wait 2 weeks.
>
> What should I do?
>
> Maxime


Hi Maxime,
I would probably listen to my pdoc. 10mg is not a high dose, and I'm sure he has considered any potential risk. However the fluoxetine/tranylcypromine interaction is of course dangerous and potentially fatal.
Take care,
Jedi

Link:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8227489&query_hl=18&itool=pubmed_docsum

J Clin Psychopharmacol. 1993 Oct;13(5):312-20.

Possible monoamine oxidase inhibitor-serotonin uptake inhibitor interaction: fluoxetine clinical data and preclinical findings.

Beasley CM Jr, Masica DN, Heiligenstein JH, Wheadon DE, Zerbe RL.

Psychopharmacology Division, Lilly Corporate Center, Indianapolis, Indiana 46285.

The primary objective of this article is to review information pertinent to and emphasize the seriousness of a potential adverse monoamine oxidase inhibitor (MAOI)-serotonin uptake inhibitor interaction by considering, within the context of preclinical data, clinical cases in which an MAOI and fluoxetine hydrochloride, a specific serotonin uptake inhibitor, were administered in close temporal proximity. Clinical cases were identified by a review of spontaneous adverse event reports submitted voluntarily to Eli Lilly and Company through its drug surveillance program and by a review of reports of MAOI interactions published in the scientific literature. A discussion of eight selected clinical cases of acute adverse reactions (seven with fatal outcomes; one with a favorable response after cyproheptadine therapy) reported to Eli Lilly and Company in which an MAOI was initiated concurrently or shortly after the discontinuation of fluoxetine and a review of preclinical data suggest a possible role of serotonin and/or serotonin-dopamine interactions in the hypermetabolic state that may occur when a serotonin uptake inhibitor and an MAOI are coadministered, although alternative etiologic processes are possible as well. Data reviewed reinforce the idea that the administration of an MAOI in close temporal proximity to fluoxetine is contraindicated.

PMID: 8227489 [PubMed - indexed for MEDLINE]


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poster:jedi thread:621369
URL: http://www.dr-bob.org/babble/20060315/msgs/621583.html