Posted by Questionmark on March 12, 2006, at 23:32:42
In reply to Re: Nardil vs. SSRI w/ augmentation » Questionmark, posted by Chairman_MAO on March 12, 2006, at 22:21:56
Thank you for your response.
Yeah, that is dissappointing (CRAP is that one S or 2; one P or 2?), though not surprising. It's crazy though. i don't understand pharmacologically how a sufficient dose of SSRI or SNRI (plus augmentation in whatever area is needed) cannot be therapeutically similar to Nardil or another hydrazine MAOI. But, you've got to be right. Nardil is not the great treatment-resistant depression and social phobia medication for nothing. Damn.Oh, i do wonder how an SSRI/SNRI with agomelatine (that new 5-HT2C antagonist & melatonin receptor agonist) might be, however (though i still do certainly doubt that it would be nearly as effective as Nardil).
Thanks for preventing me from having an idiotic treatment goal.> No dice. I'm sorry. :(
>
> I wish I could say otherwise, but MAO inhibition has a markedly different effect than that of uptake blockers. For instance, MAO-A can be found intraneuronally. This increases the amount of monoamines available for release. I have taken an SSRI+selegiline+clonazepam, SSRI+d-amphetamine+benzodiazepine, etc, etc, and all were nowhere near as effective as Nardil has been.
>
> As always, your mileage may vary.
poster:Questionmark
thread:619578
URL: http://www.dr-bob.org/babble/20060310/msgs/619660.html