Posted by Chairman_MAO on March 1, 2006, at 11:49:24
In reply to Re: MAOI-A and MAOI-B at 6mg?, posted by blueberry on March 1, 2006, at 5:40:17
The bioavailability of oral selegiline is poor. Much of it is eliminated by first-pass metabolism in the liver. Some of it binds to MAO-A in the gut.
With the patch, a majority of what gets into the bloodstream makes it to the CNS. The brain:gut ratio of MAO-A inhibition by selegiline patch in guinea pig is 7.5:1.
poster:Chairman_MAO
thread:613836
URL: http://www.dr-bob.org/babble/20060227/msgs/614633.html